Cognitex with Pregnenolone
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Cognitex with Pregnenolone

90 softgels

$59.87

Since 1982 when Cognitex was introduced to Life Extension members, the formula has been modified several times reflecting the results of new studies to promote optimal health in the aging brain. The latest version of Cognitex includes nutrients to protect the brain from a wide range of age-related insults.*

It seems the aging brain is susceptible to inflammation from enzymes known as COX-2 (cyclo-oxygenase 2) and 5-LOX (5-lipo-oxygenase). 27-33 To modify these enzymes, Nexrutine® and 5-Loxin® extracts have been added to the Cognitex formula. Nexrutine®, from a plant called Phellodendron amurense, inhibits the production of the inflammation causing COX-2 enzyme, without interfering with the beneficial enzyme COX-1 that plays a part in protecting the mucosal lining of the stomach. 34-38 * 5-Loxin® is a derivative of b-boswellic acid, a resin from the Boswellia serrata tree. 39,40 5-Loxin® modifies the agent 5-LOX. Newer research indicates that levels of 5-LOX increase with age and may trigger cell death in the brain. 41 * Inclusion of 5-Loxin® is designed to inhibit the formation of leukotriene B4, thereby balancing the effect of Nexrutine®. 42-45 *

The addition of water-soluble quercetin, a flavonoid found in fruits and vegetables such as citrus fruits, apples, onions, parsley, etc., diminishes thrombotic risk and therefore may enhance the cerebral circulation. 46,47 *

Acetylcholine is an essential neurotransmitter involved in muscular control, sleep, and cognition. 48-50 Acetylcholine levels are reduced with advancing age, resulting in neurodegeneration. 51,52 L-Alpha-glycerylphosphoryl choline (Alpha GPC) is an acetylcholine precursor derived from soy that not only boosts acetylcholine levels, but also helps to protect neuronal structure. 53-57 * Alpha GPC is a key ingredient in the Cognitex formula.

Phosphatidylserine (PS) is a natural and integral component of every cell membrane. 58-61 It is so important that the body manufactures it in order to ensure its continual supply. PS helps the brain use fuel more efficiently. 62,63 By boosting neuronal metabolism and stimulating production of acetylcholine, PS may be able to improve the condition of patients in cognitive decline. 64-67 * An added benefit is its ability to reduce levels of the stress hormone cortisol. 68,69 *

Vinpocetine, another ingredient, is a semi-synthetic derivative of the periwinkle plant that is widely used by European doctors. 70,71 Vinpocetine enhances oxygen utilization and improves circulation to the brain by allowing cerebral arteries to relax. 64,72,73 *

Pregnenolone is a natural hormone that decreases with age. 74,75 It is considered the “mother hormone” because the body converts it into a variety of other important hormones such as estrogen, progesterone, testosterone, and DHEA. 76,77 These hormones may be especially beneficial to the aging brain. 78-81 * Cognitex is available with or without pregnenolone. People with hormone-sensitive cancers should not take pregnenolone.*

Nexrutine® is a registered trademark of Next Pharmaceuticals, Inc.
5 Loxin® is a registered trade mark of PL Thomas & Co, Inc. US patent pending.

Those with prostate or estrogen-receptor positive breast cancer should not use Cognitex with pregnenolone. If you suffer from bipolar (manic-depressive) disorder, consult your doctor before using Cognitex.*