Life Extension Supplements and Products

Life Extension Supplement Products:

SAMe (S-adenosyl-methionine)
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SAMe (S-adenosyl-methionine)
400 mg, 20 tablets


SAMe (S-adenosyl-methionine) is an amino acid derivative normally synthesized in the body. SAMe is used by the body in three important pathways:

  1. Methylation (contributing methyl groups to activate certain molecules) 29,30
  2. The synthesis of polyamines (for cell growth, gene expression, neuronal regeneration, etc.) 31-33
  3. Trans-sulfuration (synthesis of cysteine, glutathione, and other sulfate chemicals) 34-36

In young, healthy people SAMe is well distributed throughout the body as a result of its synthesis from methionine by enzymes using ATP. However, in sickness and in age, system levels may become depleted. Supplementation of the co-factors folate, TMG, vitamins B6 and B12, together with SAMe appears to be an effective method to overcome this deficiency. There is evidence that SAMe helps to synthesize phosphatidylcholine, which keeps cell membranes fluid and is used in the brain to make the neurotransmitter acetylcholine. 29,30,32,35-37 *

SAMe has multi-modal mechanisms of action that are used throughout the body, and especially the liver. In order to perform its detoxification role, the liver performs large numbers of complex enzymatic reactions continually. 34,36

SAMe facilitates healthy methylation enzymatic processes and boosts hepatic levels of the critical antioxidant, glutathione. When liver function is compromised, glutathione is depleted, which leads to free radical damage. In addition, SAMe acts as a methyl donor in the synthesis and formation of phosphatidylcholine and L-cysteine, both necessary for maintaining liver health. 29,34-36 *

Supplement Facts

Serving Size 1 tablet

Servings Per Container 20

Amount Per Serving


400 mg

Other ingredients: cellulose, mannitol, hydroxypropyl methylcellulose phthalate, citric acid, sodium starch glycolate, glyceryl triacetate, croscarmellose sodium, stearic acid, silica, titanium dioxide, yellow ochre.

Dosage and Use

800-1200 mg (2-3) per day is recommended.


Take in divided doses morning, midday, and late afternoon.


Taking this product with food may avoid gastrointestinal disturbance.


Refrigeration is recommended.


Those supplementing with SAMe should also take folic acid, vitamin B12, vitamin B6 and TMG (trimethylglycine, betaine). SAMe should not be used by those with bipolar disorder (manic depressive psychosis) or those with suicidal thoughts or feelings.




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*These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.